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Title: Rnaseh1  
Author: World Heritage Encyclopedia
Language: English
Subject: R.EcoRII, POLD4, Autonomously replicating sequence, T7 DNA helicase, HolD
Publisher: World Heritage Encyclopedia


Ribonuclease H1

PDB rendering based on 2qk9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; H1RNA; RNH1
External IDs ChEMBL: GeneCards:
EC number
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene.[1][2][3] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.


  1. ^ "Entrez Gene: ribonuclease H1". 
  2. ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (June 2002). "Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome". Genomics 79 (6): 818–23.  
  3. ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (October 2007). "Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription". Mol. Cell 28 (2): 264–76.  

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