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4-Dimethylaminophenol

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4-Dimethylaminophenol

4-Dimethylaminophenol
Identifiers
CAS number  N
PubChem
ChemSpider  YesY
UNII  YesY
ATC code V03
Jmol-3D images Image 1
Properties
Molecular formula C8H11NO
Molar mass 137.179 g/mol
Boiling point 165 °C (329 °F; 438 K) (0.040 bar)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N   YesY/N?)

4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1] It has also been shown to be effective in treating hydrogen sulfide toxicity.[2]

It works by generating methemoglobin. [3]

This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.

In an animal model, it has shown effectiveness when given intramuscularly.[4] Though, intramuscular injection should be avoid due to the probability of muscular necrosis after injection. Intravenous injection is recommended in a dose of 250mg.[5]

See also

References

  1. ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91.  
  2. ^ Lindenmann J, Matzi V, Neuboeck N, Ratzenhofer-Komenda B, Maier A, Smolle-Juettner FM (December 2010). "Severe hydrogen sulphide poisoning treated with 4-dimethylaminophenol and hyperbaric oxygen". Diving and Hyperbaric Medicine : the Journal of the  
  3. ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16.  
  4. ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9.  
  5. ^ Federation Of American Scientists (1 February 1996). "NATO HANDBOOK ON THE MEDICAL ASPECTS OF NBC DEFENSIVE OPERATIONS". p. 334. 
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