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Anxa2

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Anxa2

Annexin A2
PDB rendering based on 1w7b.
Available structures
PDB Ortholog search: RCSB
Identifiers
ANXA2 Gene
RNA expression pattern

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.[1]

Annexin 2 is involved in diverse cellular processes such as cell motility (especially that of the epithelial cells), linkage of membrane-associated protein complexes to the actin cytoskeleton, endocytosis, fibrinolysis, ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body.

Gene

The ANXA2 gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

Function

This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.[2]

Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant reactions.

Interactions

Annexin A2 has been shown to interact with Prohibitin,[3] CEACAM1,[4] S100A10,[5][6] PCNA[7] and complement Factor H [8]

See also

References

Further reading

External links

  • Medical Subject Headings (MeSH)
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