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Antibody mimetic

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Antibody mimetic

Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They are usually artificial peptides or proteins with a molar mass of about 3 to 20 kDa. Nucleic acids and small molecules are sometimes considered antibody mimetics as well, but not artificial antibodies, antibody fragments and fusion proteins composed from these. Some types have an antibody-like beta-sheet structure. Common advantages over antibodies are better solubility, tissue penetration, stability towards heat and enzymes, and comparatively low production costs. Antibody mimetics are being developed as therapeutic and diagnostic agents.[1]

Examples

Antibody mimetic Scaffold Molar mass Example drug
Affibody molecules[2] Z domain of Protein A 6 kDa ABY-025
Affilins[3] Gamma-B crystallin 20 kDa
Ubiquitin 10 kDa SPVF 2801
Affitins[4] Sac7d (from Sulfolobus acidocaldarius) 7 kDa
Anticalins[5] Lipocalins 20 kDa
Avimers[6] A domains of various membrane receptors 9–18 kDa
DARPins[7] Ankyrin repeat motif 10–19 kDa MP0112
Fynomers[8] SH3 domain of Fyn 7 kDa
Kunitz domain peptides[9] Kunitz domains of various protease inhibitors 6 kDa Ecallantide (Kalbitor)
Monobodies[10] 10th type III domain of fibronectin 10 kDa Pegdinetanib (Angiocept)

References

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