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Appendix cancer

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Title: Appendix cancer  
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Subject: Audrey Hepburn, Gastrointestinal cancer, Pseudomyxoma peritonei, Chinatsu Mori, Colorectal adenoma
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Appendix cancer

Appendix cancer
Classification and external resources
Specialty Oncology
ICD-10 C18.1, C78.5
ICD-9-CM 153.5
MeSH D001063

Appendix cancer or appendiceal cancers are rare malignancies of the vermiform appendix.

Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast cancer, colon cancer, and tumors of the female genital tract may metastasize to the appendix.[1]


  • Treatment 1
  • Epidemiology 2
  • Notable cases 3
  • References 4
  • Further reading 5
  • External links 6


The treatment for tumors varies. Small carcinoids (<2 cm) without features of malignancy may be treated by appendectomy if complete removal is possible. Other carcinoids and adenocarcinomas may require right hemicolectomy. Note: the term "carcinoids" is outdated: these tumors are now more accurately called "neuroendocrine tumors." For more information, see "appendiceal neuroendocrine tumors."[2]

chemotherapy known as HIPEC in an attempt to eradicate residual disease. The surgery may or may not be preceded or followed with intravenous chemotherapy or HIPEC.[3]


A study of primary malignacies in the United States found a rate of 0.12 cases per 1,000,000 population per year. Carcinoids that were not identified as malignant were not included in this data.[4] Carcinoid is found in roughly 1 in 300 appendectomies for acute appendicitis. A Hong Kong case series of 1492 appendectomies identified 17 neoplasms. Eight were carcinoids without specification of malignant features. Three cases of adenocarcinoma, and one each of cystadenocarcinoma, psedomyxoma peritoneii, and metastasic carcinoma were identified. The remaining tumors were benign.[5] It was previously believed that carcinoid tumors are the most common tumors of the appendix but now data from the SEER program show that mucinous adenocarcinomas are more common.[6]

Notable cases

Actress Audrey Hepburn was diagnosed with appendix cancer, and she died of the disease in 1993.[7]

In 2007, ESPN sportscast anchor Stuart Scott was diagnosed with appendiceal cancer, and he died of the disease in 2015.[8][9]

Serbian musician Vlada Divljan was diagnosed with the cancer in 2012, and he died of subsequent complications in 2015.[10]


  1. ^  
  2. ^ Griniatsos, J; Michail, O (2010). "Appendiceal neuroendocrine tumors: recent insights and clinical implications.". World Journal of Gastrointestinal Oncology. 2 (4): 192-196.  
  3. ^ M. Townsend, Courtney (2012) [1969]. "51. The appendix". Sabiston (18th ed.). Elsevier. p. 1289. 
  4. ^ McCusker, M. E.; Coté, T. R.; Clegg, L. X.; Sobin, L. H. (2002). "Primary malignant neoplasms of the appendix". Cancer 94 (12): 3307–3312.  
  5. ^ Ma, KW; Chia, NH; Yeung, HW; Cheung, MT (2010). "If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies". Hong Kong medical 16 (1): 12–7.  
  6. ^ Sabiston Principles of Surgery (18th ed.). p. 1344. 
  7. ^ Selim, Jocelyn (Fall 2009), "The Fairest of All", CR (Philadelphia: American Association for Cancer Research) 4 (4), retrieved January 22, 2011 
  8. ^ "'"Stuart Scott Says, 'F U, Cancer!. Men's Health. Retrieved 7 January 2015. 
  9. ^ "Stuart Scott, ESPN’s Voice of Exuberance, Dies at 49". New York Times. Retrieved 7 January 2015. 
  10. ^ "Vlada Divljan poručio: Nisam životno ugrožen, osećam se vrlo dobro" (in Serbian). Blic. 30 January 2015. Retrieved 10 March 2015. 

Further reading

  • Hamilton, S.R.; Aaltonen, L.A., eds. (2000). "Ch. 5 Tumours of the Appendix". World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System (PDF). Lyon:  
  • McGory, Marcia L.; Maggard, Melinda A.; Kang, Hakjung; O'Connell, Jessica B.; et al. (2005). "Malignancies of the appendix: Beyond case series reports". Diseases of the Colon & Rectum 48 (12): 2264–71.  
  • O'Donnell, M.E.; Carson, J.; Garstin, W.I.H. (2006). "Surgical treatment of malignant carcinoid tumours of the appendix". International Journal of Clinical Practice 61 (3): 431–7.  
  • Goede, A.C.; Caplin, M.E.; Winslet, M.C. (2003). "Carcinoid tumour of the appendix".  
  • Stinner, B.; Rothmund, M. (2005). "Neuroendocrine tumours (carcinoids) of the appendix". Best Practice & Research: Clinical Gastroenterology 19 (5): 729–38.  

External links

  • Cancer.Net: Appendix Cancer
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