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Title: Chromatid  
Author: World Heritage Encyclopedia
Language: English
Subject: Chromosome, Telomere, Chromosomal crossover, Centromere, Chromatin
Collection: Cell Biology, Chromosomes, Mitosis, Molecular Genetics, Telomeres
Publisher: World Heritage Encyclopedia


In the diagram, (1) refers to a chromatid: one-half of two identical threadlike strands of a replicated chromosome. During cell division, the identical copies (called a "sister chromatid pair") are joined at the region called the centromere (2). Once the paired sister chromatids have separated from one another (in the anaphase of mitosis) each is known as a daughter chromosome. The short arm of the left chromatid (3), and the long arm of the right chromatid (4), are also marked.

A chromatid (Greek khrōmat- 'color' + -id) is one copy of a newly replicated chromosome, which typically is joined to the other copy by a single centromere.

Before replication, one chromosome is composed of one DNA (double-helix) molecule. Following replication, each chromosome is composed of two DNA molecules; in other words, DNA replication itself increases the amount of DNA but does not increase the number of chromosomes. The two identical copies—each forming one half of the replicated chromosome—are called chromatids.[1] During the later stages of cell division these chromatids separate longitudinally to become individual chromosomes.[2]

Chromatid pairs are normally genetically identical, and said to be homologous versions of a chromosome.

Chromonema is the fibre-like structure in prophase in the primary stage of DNA condensation. In metaphase,they are called chromatids.

Brother vs. sister chromatids

Chromatids may be sister or non-sister chromatids. In general, sister chromatids are either of the two chromatids of the same chromosome joined together by a common centromere. Once sister chromatids have separated (during the anaphase of mitosis or the anaphase II of meiosis during sexual reproduction), the strands are called daughter chromosomes. Although having the same genetic mass as the individual chromatids that made up its parent, the daughter "molecules" are called chromosomes in a similar way that one child of a pair of twins is not referred to as a single twin.

A non-sister chromatid, on the other hand, refers to either of the two chromatids of paired homologous chromosomes, that is, the pairing of a paternal chromosome and a maternal chromosome. Non-sister (homologous) chromatids form chiasmata to exchange genetic material during the prophase I of meiosis.


  1. ^ Chromatid - A Cell Biology Definition
  2. ^
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