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Title: Coagulopathy  
Author: World Heritage Encyclopedia
Language: English
Subject: Bleeding diathesis, Hematologic disease, Platelet storage pool deficiency, Bernard–Soulier syndrome, Amniotic fluid embolism
Collection: Bleeding, Coagulopathies
Publisher: World Heritage Encyclopedia


Classification and external resources
ICD-10 D65-D68
ICD-9-CM 286
DiseasesDB 29158
MeSH D001778

Coagulopathy (also called a clotting disorder) is a condition in which the blood’s ability to coagulate (form clots) is impaired.[1] This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis or bleeding disorder), which may occur spontaneously or following an injury or medical and dental procedures.


  • Signs and symptoms 1
  • Mechanism 2
  • Treatment 3
    • Critical Care 3.1
  • See also 4
  • References 5

Signs and symptoms

Coagulopathy may cause uncontrolled internal or external bleeding. Left untreated, uncontrolled bleeding may cause damage to joints, muscles, or internal organs and may be life-threatening. People should seek immediate medical care for serious symptoms, including heavy external bleeding, blood in the urine or stool, double vision, severe head or neck pain, repeated vomiting, difficulty walking, convulsions, or seizures. They should seek prompt medical care if they experience mild but unstoppable external bleeding or joint swelling and stiffness.


The normal clotting process depends on the interplay of various proteins in the blood. Coagulopathy may be caused by reduced levels or absence of blood-clotting proteins, known as clotting factors or coagulation factors. Genetic disorders, such as hemophilia and Von Willebrand's disease, can cause a reduction in clotting factors.[2] Anticoagulants such as warfarin will also prevent clots from forming properly.[2] Coagulopathy may also occur as a result of dysfunction or reduced levels of platelets (small disk-shaped bodies in the bloodstream that aid in the clotting process).


If someone has coagulopathy, their health care provider may help them manage their symptoms with medications or replacement therapy. In replacement therapy, the reduced or absent clotting factors are replaced with proteins derived from human blood or created in the laboratory. This therapy may be given either to treat bleeding that has already begun or to prevent bleeding from occurring.

Critical Care

One area of treatment is managing people with major bleeding in a critical setting, like an emergency department.[1] In these situations, the common treatment is transfusing a combination of red cells with one of the following options:

The use of hemorrhage, and venous thromboembolism.

See also


  1. ^ a b Hunt, Beverley J. (2014). "Bleeding and Coagulopathies in Critical Care". New England Journal of Medicine 370 (9): 847–859.  
  2. ^ a b Spahn, DR.; Bouillon, B.; Cerny, V.; Coats, TJ.; Duranteau, J.; Fernández-Mondéjar, E.; Filipescu, D.; Hunt, BJ.; et al. (Apr 2013). "Management of bleeding and coagulopathy following major trauma: an updated European guideline". Crit Care 17 (2): R76.  
  3. ^ Shakur, Haleema; Roberts, Ian; Perel, Pablo (2010). "Tranexamic acid for trauma – Authors' reply". The Lancet 376 (9746): 1050–1051.  
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