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Title: Entpd1  
Author: World Heritage Encyclopedia
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Subject: CD153, CD109, CD1E, CD25, CD320
Collection: Clusters of Differentiation
Publisher: World Heritage Encyclopedia


Ectonucleoside triphosphate diphosphohydrolase 1
Symbols  ; ATPDase; CD39; NTPDase-1; SPG64
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) also known as CD39 (Cluster of Differentiation 39), is a human membrane-bound protein.[1] CD39, an ectonucleotidase like CD73, hydrolyzes ATP and ADP to AMP.


  • See also 1
  • References 2
  • Further reading 3
  • External links 4

See also


  1. ^ "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1". 

Further reading

  • Maliszewski CR, Delespesse GJ, Schoenborn MA et al. (1994). "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". J. Immunol. 153 (8): 3574–83.  
  • Christoforidis S, Papamarcaki T, Galaris D et al. (1996). "Purification and properties of human placental ATP diphosphohydrolase". Eur. J. Biochem. 234 (1): 66–74.  
  • Wang TF, Guidotti G (1996). "CD39 is an ecto-(Ca2+,Mg2+)-apyrase". J. Biol. Chem. 271 (17): 9898–901.  
  • Kaczmarek E, Koziak K, Sévigny J et al. (1997). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". J. Biol. Chem. 271 (51): 33116–22.  
  • Robson SC, Kaczmarek E, Siegel JB et al. (1997). "Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation". J. Exp. Med. 185 (1): 153–63.  
  • Gray IC, Fallowfield J, Ford S et al. (1997). "An integrated physical and genetic map spanning chromosome band 10q24". Genomics 43 (1): 85–8.  
  • Makita K, Shimoyama T, Sakurai Y et al. (1999). "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation". Int. J. Hematol. 68 (3): 297–310.  
  • Matsumoto M, Sakurai Y, Kokubo T et al. (1999). "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II". FEBS Lett. 453 (3): 335–40.  
  • Kittel A, Kaczmarek E, Sevigny J et al. (1999). "CD39 as a caveolar-associated ectonucleotidase". Biochem. Biophys. Res. Commun. 262 (3): 596–9.  
  • Koziak K, Kaczmarek E, Kittel A et al. (2000). "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae". J. Biol. Chem. 275 (3): 2057–62.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6.  
  • Goepfert C, Imai M, Brouard S et al. (2001). "CD39 modulates endothelial cell activation and apoptosis". Mol. Med. 6 (7): 591–603.  
  • Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta 1492 (1): 127–38.  
  • Kittel A, Garrido M, Varga G (2002). "Localization of NTPDase1/CD39 in normal and transformed human pancreas". J. Histochem. Cytochem. 50 (4): 549–56.  
  • Kaneider NC, Egger P, Dunzendorfer S et al. (2002). "Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism". Arterioscler. Thromb. Vasc. Biol. 22 (6): 894–900.  
  • Drosopoulos JH (2002). "Roles of Asp54 and Asp213 in Ca2+ utilization by soluble human CD39/ecto-nucleotidase". Arch. Biochem. Biophys. 406 (1): 85–95.  
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Krötz F, Sohn HY, Keller M et al. (2002). "Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2003–9.  
  • Rossatto ER, da Silva LB, Pereira GS et al. (2003). "ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease". Platelets 14 (1): 47–52.  
  • Sørensen CE, Amstrup J, Rasmussen HN et al. (2004). "Rat pancreas secretes particulate ecto-nucleotidase CD39". J. Physiol. (Lond.) 551 (Pt 3): 881–92.  

External links

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