Fibrinogen alpha chain

PDB rendering based on 1fza.

Available structures

Ortholog search: RCSB

List of PDB id codes
4F27

Identifiers

FGA Gene

Gene Ontology
Molecular function	• eukaryotic cell surface binding
Cellular component	• platelet alpha granule lumen
Biological process	• response to calcium ion
Sources: QuickGO

RNA expression pattern

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.^[1]

1 Interactions
2 See also
3 References
4 Further reading

Interactions

Fibrinogen alpha chain has been shown to interact with Tissue plasminogen activator.^[2]^[3]

References

Primary hemostasis	vWF platelet membrane glycoproteins: Ib (A B IX) IIb/IIIa (IIb IIIa) VI

Intrinsic pathway	HMWK/Bradykinin Prekallikrein/Kallikrein XII "Hageman" XI IX VIII

Extrinsic pathway	III "Tissue factor" VII

Common pathway	X V II "(Pro)thrombin" I "Fibrin" Fibrinogen (FGA, FGG) XIII

Coagulation inhibitors

Thrombolysis/fibrinolysis

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

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Fibrinogen alpha chain