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Glypican 3

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Glypican 3

Glypican 3
GPC3 Gene
RNA expression pattern

Glypican-3 is a protein that in humans is encoded by the GPC3 gene.[1][2][3][4] The protein encoded by this gene is a member of the glypican family.

Structure and function

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[3]

Disease linkage

Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome.[5]

Diagnostic utility

Glypican 3 immunostaining has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with glypican 3, while liver with dysplastic changes and/or cirrhotic changes does not.[6]

See also

External links

  • GeneReviews/NIH/NCBI/UW entry on Simpson-Golabi-Behmel Syndrome


Further reading

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