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Title: Hydia  
Author: World Heritage Encyclopedia
Language: English
Subject: Eglumegad, LY-487,379, LY-379,268, DNQX, DCPG
Collection: Mglu2 Receptor Antagonists, Mglu3 Receptor Antagonists, Neuroscience, Pharmacology
Publisher: World Heritage Encyclopedia


Systematic (IUPAC) name
(1S,2R,3R,5R,6S)-2-amino-3-hydroxybicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Clinical data
Legal status
ATC code ?
ChemSpider  N
Chemical data
Formula C8H11NO5 
Mol. mass 201.176 g/mol

HYDIA is a drug that is used in neuroscience research, which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3). It has been useful in the mapping of the group II mGluR receptor proteins and their molecular modeling.[1] HYDIA is similar in structure to group II mGluR agonists such as eglumegad and LY-404,039, but the addition of the 3-hydroxy group reverses the activity to a competitive antagonist. Other derivatives such as the 3-benzyloxy ether are more potent antagonists than HYDIA itself.[2]


  1. ^ Lundström L, Kuhn B, Beck J, Borroni E, Wettstein JG, Woltering TJ, Gatti S (July 2009). "Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA". Chemmedchem 4 (7): 1086–94.  
  2. ^ Woltering TJ, Adam G, Huguenin P, Wichmann J, Kolczewski S, Gatti S, Bourson A, Kew JN, Richards G, Kemp JA, Mutel V, Knoflach F (February 2008). "Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA". Chemmedchem 3 (2): 323–35.  

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