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Title: Ing1  
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Subject: P53, SIN3A, Transcription factors, NeuroD, EMX homeogene
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Inhibitor of growth family, member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
External IDs GeneCards:
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3] This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2


ING1 has been shown to interact with HDAC1,[4][5] DMAP1,[6] PCNA,[7] SIN3A,[5] SAP30,[5] P53,[8][9] SMARCC1,[5] CREB binding protein[4] and SMARCA4.[5]


  1. ^ Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (Jan 1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Nat Genet 14 (4): 415–20.  
  2. ^ Garkavtsev I, Demetrick D, Riabowol K (Jul 1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)". Cytogenet Cell Genet 76 (3-4): 176–8.  
  3. ^ a b "Entrez Gene: ING1 inhibitor of growth family, member 1". 
  4. ^ a b Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl (Aug 2002). "Human ING1 proteins differentially regulate histone acetylation". J. Biol. Chem. (United States) 277 (33): 29832–9.  
  5. ^ a b c d e Kuzmichev, A; Zhang Y; Erdjument-Bromage H; Tempst P; Reinberg D (Feb 2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Mol. Cell. Biol. (United States) 22 (3): 835–48.  
  6. ^ Xin, Huawei; Yoon Ho-Guen; Singh Prim B; Wong Jiemin; Qin Jun (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. (United States) 279 (10): 9539–46.  
  7. ^ Scott, M; Bonnefin P; Vieyra D; Boisvert F M; Young D; Bazett-Jones D P; Riabowol K (Oct 2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis". J. Cell. Sci. (England) 114 (Pt 19): 3455–62.  
  8. ^ Leung, Ka Man; Po Lai See; Tsang Fan Cheung; Siu Wai Yi; Lau Anita; Ho Horace T B; Poon Randy Y C (Sep 2002). "The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2". Cancer Res. (United States) 62 (17): 4890–3.  
  9. ^ Garkavtsev, I; Grigorian I A; Ossovskaya V S; Chernov M V; Chumakov P M; Gudkov A V (Jan 1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control".  

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