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Title: Isovaleramide  
Author: World Heritage Encyclopedia
Language: English
Subject: Valerian (herb)
Publisher: World Heritage Encyclopedia


CAS number 541-46-8 YesY
PubChem 10930
KEGG D04637 YesY
Jmol-3D images Image 1
Molecular formula C5H11NO
Molar mass 101.15 g mol−1
Appearance colourless solid
Melting point

137 °C, 410 K, 279 °F

Boiling point

226 °C, 499 K, 439 °F

 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.

Occurrence and biological activity

Isovaleramide is found in the Valerian root.

In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages.[1] Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported LD50 of greater than 400 mg/kg when administered intraperitoneally in mice.[2]


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