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Lilrb2

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Title: Lilrb2  
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Lilrb2

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

PDB rendering based on 2dyp.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; CD85D; ILT-4; ILT4; LIR-2; LIR2; MIR-10; MIR10
External IDs GeneCards:
Orthologs
Species Human Mouse
Entrez n/a
Ensembl n/a
UniProt n/a
RefSeq (mRNA) n/a
RefSeq (protein) n/a
Location (UCSC) n/a
PubMed search n/a

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.[1][2][3] This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

LILRB2 has been shown to interact with PTPN6.[4][5]

See also

References

  1. ^ Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med 185 (10): 1743–51.  
  2. ^ Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5.  
  3. ^ a b "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2". 
  4. ^ Fanger, N A; Cosman D; Peterson L; Braddy S C; Maliszewski C R; Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. (GERMANY) 28 (11): 3423–34.  
  5. ^ Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. (UNITED STATES) 160 (7): 3096–100.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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