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Liver sinusoid

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Title: Liver sinusoid  
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Subject: Liver, Central veins of liver, Lobules of liver, Hepatic portal system, Periportal space
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Liver sinusoid

Liver sinusoid
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm.
Basic liver structure
Latin vas sinusoideum
Code TH H3.
Anatomical terminology

A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.[1]

Hepatocytes are separated from the sinusoids by the space of Disse. Kupffer cells are located inside the sinusoids and can take up and destroy foreign material such as bacteria.


The sinusoidal endothelial cells are cultured for a variety of research purposes. The utility of these cells are of particular interest. One problem to overcome the reversing of cellular differentiation that have made these cells highly specialized phenotypically in vitro.[2]

Additional images


  1. ^ SIU SOM Histology GI
  2. ^ Sellaro TL, Ravindra AK, Stolz DB, Badylak SF. (September 2007). "Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds". Tissue Eng. 13 (9): 2301–2310.  

External links

  • UIUC Histology Subject 589
  • Histology image: 15504loa - Histology Learning System at Boston University - "Liver, Gall Bladder, and Pancreas: liver, classic lobule"
  • Histology image: 22103loa - Histology Learning System at Boston University - "Ultrastructure of the Cell: hepatocytes and sinusoids, sinusoid and space of Disse"
  • Histology at

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