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Title: Mst1r  
Author: World Heritage Encyclopedia
Language: English
Subject: DDR1, TEK tyrosine kinase, Kinase insert domain receptor, PDGFRB, Anaplastic lymphoma kinase
Publisher: World Heritage Encyclopedia


Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols  ; CD136; CDw136; PTK8; RON
External IDs ChEMBL: GeneCards:
EC number
RNA expression pattern
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[1][2] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[1][3]


MST1R has been shown to interact with Grb2.[4][5]


  1. ^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene 8 (5): 1195–202.  
  2. ^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)". 
  3. ^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32.  
  4. ^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8.  
  5. ^ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75.  

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