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Norepinephrine (medication)

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Title: Norepinephrine (medication)  
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Subject: Inotropic agents, Norepinephrine, Sepsis
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Norepinephrine (medication)

Norepinephrine (INN)
Systematic (IUPAC) name
Clinical data
Trade names Levarterenol, Levophed, Norepin
Licence data US FDA:
  • AU: B3
  • US: C (Risk not ruled out)
Legal status
Routes of
Pharmacokinetic data
Metabolism Hepatic
Excretion Urine (84–96%)
CAS Registry Number  Y
ATC code C01
PubChem CID:
DrugBank  Y
ChemSpider  Y
Synonyms Noradrenaline
Chemical data
Formula C8H11NO3
Molecular mass 169.18 g/mol
Physical data
Density 1.397±0.06 g/cm3
Melting point 217 °C (423 °F) (decomposes)
Boiling point 442.6 °C (828.7 °F) ±40.0°C

Norepinephrine (INN), also known as noradrenaline (BAN) is used as a vasopressor medication for people with critically low blood pressure. It is given intravenously and acts on both α1 and α2 adrenergic receptors to cause blood vessel contraction. Its effects are often limited to the increasing of blood pressure through agonist activity on α1 and α2 receptors, and causing a resultant increase in peripheral vascular resistance. At high doses, and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death. Norepinephrine is used mainly to treat patients in vasodilatory shock states such as septic shock and neurogenic shock, while showing fewer adverse side-effects compared to dopamine treatment.[1]


  1. ^ De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL (March 2010). "Comparison of dopamine and norepinephrine in the treatment of shock". The New England Journal of Medicine 362 (9): 779–89.  
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