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Paleogenetics

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Title: Paleogenetics  
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Paleogenetics

Paleogenetics is the study of the past through the examination of preserved


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  2. ^ a b c Pauling L, Zuckerkand E, Henriksen T, Lövstad R (1963). "Chemical Paleogenetics: Molecular "Restoration Studies" of Extinct Forms of Life". Acta Chemica Scandinavica 17 (supl.): 9–16.  
  3. ^ Higuchi R, Bowman B, Freiberger M, Ryder OA, Wilson AC (1984). "DNA sequences from the quagga, an extinct member of the horse family". Nature 312 (5991): 282–4.  
  4. ^ Gibbons, A (December 2010). "Tiny time machines revisit ancient life". Science 330 (6011): 1616.  
  5. ^ a b c d Geigl E-M (2008). "Palaeogenetics of cattle domestication: Methodological challenges for the study of fossil bones preserved in the domestication centre in Southwest Asia". Comptes Rendus Palevol 7 (2–3): 99–112.  
  6. ^ Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, Patterson N, Li H, Zhai W; et al. (May 2010). "A draft sequence of the Neanderthal genome". Science 328 (5979): 710–22.  
  7. ^ a b c d e f Saey TH (2009). "Story one: Team decodes neanderthal DNA: Genome draft may reveal secrets of human evolution". Science News 175 (6): 5–7.  
  8. ^ Zorich Z (2010). "Neanderthal Genome Decoded". Archaeology (Archaeological Institute of America) 63 (4). 
  9. ^ a b c Keller A, Graefen A, Ball M, Matzas M, Boisguerin V, Maixner F, Leidinger P, Backes C, Khairat R; et al. (2012). "New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing". Nature Communications 3 (2): 698.  
  10. ^ Kaplan, Matt. DNA has a 521-year half-life. Nature News, 10 October 2012.
  11. ^ Wickman, Forrest. What’s the Shelf-Life of DNA? Slate, 5 February 2013.

References

See also

[5], bone may also become contaminated with modern DNA (i.e. from contact with skin or unsterilized tools), which can create false-positive results.excavation After [5] In addition, DNA degrades much more quickly following excavation of materials, and freshly excavated bone has a much higher chance of containing viable genetic material.[11] or caves, where remains may persist in cold, low oxygen conditions for several hundred thousand years.permafrost in dead tissue by biotic and abiotic factors once repair enzymes present in living tissue cease to be functional. DNA preservation is dependent on a number of environmental characteristics, including temperature, humidity, oxygen and sunlight. Remains from regions with high heat and humidity typically contain less intact DNA than those from degradation of DNA This is due to the [10][2] Ancient remains usually contain only a small fraction of the original

Challenges

Not only can past humans be investigated through paleogenetics, but the organisms they had an effect on can also be examined. Through examination of the divergence found in domesticated species such as cattle and the archaeological record from their wild counterparts; the effect of domestication can be studied, which could tell us a lot about the behaviors of the cultures that domesticated them. The genetics of these animals also reveals traits not shown in the paleontological remains, such as certain clues as to the behavior, development, and maturation of these animals. The diversity in genes can also tell where the species were domesticated, and how these domesticates migrated from these locations elsewhere.[5]

Domestication of Animals

The oldest case of Lyme disease was discovered in the genome on a man called Ötzi the Iceman.[9] Ötzi died around 3,300 B.C., and his remains were discovered in the Eastern Alps in the early 1990s.[9] An analysis of his genes was not run until 20 years later. Genetic remains of the bacterium that cause Lyme disease, Borrelia burgdorferi, were discovered in genetic material from Ötzi.[9]

Ötzi

Studying DNA of the deceased also allows us to look at the medical history of the human race. By looking back we can discover when certain diseases first appeared and began to afflict humans.

Ancient disease

Archaeology

Looking at DNA can give insight into lifestyles of people of the past. Neandertal DNA shows that they lived in small temporary communities.[7] DNA analysis can also show dietary restrictions and mutations, such as the fact that Homo neanderthalensis was lactose-intolerant.[7]

Evolution of culture

Paleogenetics opens up many new possibilities for the study of hominid evolution and dispersion. By analyzing the genomes of hominid remains, their lineage can be traced back to from where they came, or from where they share a common ancestor. The Denisova hominid, a species of hominid found in Siberia from which DNA was able to be extracted, may show signs of having genes that are not found in any Neanderthal nor Homo sapiens genome, possibly representing a new lineage or species of hominid.[8]

Using the thigh bone of a Neanderthal female, 63% of the Neanderthal genome was uncovered and 3.7 billion bases of DNA were decoded.[6][7] It showed that Homo neanderthalensis was the closest living relative of Homo sapiens, until the former lineage died out 30,000 years ago. The Neanderthal genome was shown to be within the range of variation of those of anatomically modern humans, although at the far periphery of that range of variation. Paleogenetic analysis also suggests that Neanderthals shared more DNA with chimpanzees than homo sapiens.[7] It was also found that Neanderthals were less genetically diverse than modern humans are, which indicates that Homo neanderthalensis grew from a group composed of relatively few individuals.[7] DNA sequences suggest that Homo sapiens first appeared between about 130,000 and 250,000 years ago in Africa.[7]

Human evolution

Similar sequences are often found along natural selection, these similarities can be plausibly linked to the existence of a common ancestor with common genes. This allows polypeptide sequences to be compared between species, and the difference between two genetic sequences can be used to determine - within error - the time at which a common ancestor existed.[2]

Evolution

Applications

Contents

  • Applications 1
    • Evolution 1.1
      • Human evolution 1.1.1
    • Evolution of culture 1.2
  • Archaeology 2
    • Ancient disease 2.1
      • Ötzi 2.1.1
    • Domestication of Animals 2.2
  • Challenges 3
  • See also 4
  • References 5

Paleogeneticists do not recreate actual organisms, but piece together ancient DNA sequences using various analytical methods.[4] In many ways, an organism's genetics are "the only direct witnesses of extinct species and of evolutionary events".[5]

[3].Allan Wilson, was published in 1984 by a team led by quagga, isolated from a museum specimen of the extinct ancient DNA The first sequence of an [2] sequences.polypeptide introduced the term "paleogenetics" in 1963, in reference to the examination of possible applications in the reconstruction of past Linus Carl Pauling and the physical chemist Emile Zuckerkandl [1]

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