World Library  
Flag as Inappropriate
Email this Article

Parafollicular cells

Article Id: WHEBN0003057504
Reproduction Date:

Title: Parafollicular cells  
Author: World Heritage Encyclopedia
Language: English
Subject: Thyroid
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Parafollicular cells

Parafollicular cell
Code Template:TerminologiaHistologica

Parafollicular cells (also called C cells) are neuroendocrine cells in the thyroid with primary function to secrete calcitonin. They are located adjacent to the thyroid follicles and reside in the connective tissue. These cells are large and have a pale stain compared with the follicular cells or colloid. In teleost and avian species these cells occupy a structure outside of the thyroid gland named the ultimobranchial body.

Parafollicular cells themselves are derived from neural crest cells. Embryologically, they associate with the ultimobranchial body, which itself is a ventral derivative of the fourth (or fifth) pharyngeal pouch. In a series of experiments, Nicole LeDouarin transplanted neural crest cells from quail, with unique and easily identified nuclei, into non-quail neural crest. She subsequently demonstrated the presence of cells with quail nuclei populating the ultimobranchial body and concluded that C cells migrate during embryologic development from the neural crest.[1][2]

They are not numerous in the thyroid and are typically situated basally in the epithelium, without direct contact with the follicular lumen. They are always situated within the basement membrane, which surrounds the entire follicle.

Parafollicular cell are also known to secrete in smaller quantities several neuroendocrine peptides such as serotonin, somatostatin or CGRP.[3][4][5] They may also have a paracrine role in regulating thyroid hormones production, as they express TRH.[6][7]

When parafollicular cells become cancerous, they lead to medullary carcinoma of the thyroid.

Literature

  • Baber EC: Contributions to the minute anatomy of the thyroid gland of the dog. Phil Trans R Soc 166 (1876) 557-568 (full text)

References

External links

  • 42_04
  • 14302loa
  • endo-/endo10
  • Anatomy Atlases - Microscopic Anatomy, plate 15.287
This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.