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Phosphatidylinositol

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Title: Phosphatidylinositol  
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Phosphatidylinositol

Phosphatidylinositol
Names
Other names
PI, PtdIns
Properties
C47H83O13P
Molar mass 886.56 g/mol, neutral with fatty acid composition - 18:0, 20:4
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 Y  (: Y/N?)

Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides. In such molecules the isomer of the inositol group is assumed to be the myo- conformer unless otherwise stated. Typically phosphatidylinositols form a minor component on the cytosolic side of eukaryotic cell membranes. The phosphate group gives the molecules a negative charge at physiological pH.

The form of phosphatidylinositol comprising the isomer muco-inositol acts as a sensory receptor in the taste function of the sensory system. In this context it is often referred to as PtdIns, but that does not imply any molecular difference from phosphatidylinositols comprising the myo- conformers of inositol.

The phosphatidylinositol can be phosphorylated to form phosphatidylinositol phosphate (PI-4-P, referred to as PIP in close context or informally), phosphatidylinositol bisphosphate (PIP2) and phosphatidylinositol trisphosphate (PIP3). All lipids based on phosphatidylinositol are known as inositides, or sometimes phosphoinositides.

Contents

  • Biosynthesis 1
  • Chemistry 2
  • Phosphoinositides 3
  • See also 4
  • References 5
  • Additional images 6
  • External links 7

Biosynthesis

The neurologically important PtdIns are synthesized as a liquid crystalline region in the outer lemma of the cilia of the sodium path (Na path) sensory receptors exposed to the mucosa in mammals and some other vertebrates (Family Chordata). This specific form of phosphatidylinositol formed with -Inositolmuco (CAS 488-55-1) is NOT shown at right. This compound forms the sensory receptor of the sodium path under the molecular biochemical model of the gustatory modality.

Biosynthesis of phosphatidylinositol catalyzed by phosphatidylinositol synthase. Figure adapted from Christopher, K.; van Holde, K.E.; Ahern, Kevin G. Biochemistry Third Edition. Pearson Education, Inc: Singapore, 2005; p 678.[1]

The synthesis of phosphatidylinositol in the laboratory is catalyzed by phosphatidylinositol synthase and involves CDP-diacylglycerol and L-myo-inositol.[1]

Chemistry

PI has a polar and non-polar region, making the lipid an amphiphile. Phosphatidylinositol is classified as a glycerophospholipid that contains a glycerol backbone, two non-polar fatty acid tails, a phosphate group substituted with an inositol polar head group.

The most common fatty acids of phosphoinositides are stearic acid in the SN1 position and arachidonic acid, in the SN2 position. Hydrolysis of phosphoinositides yield one mole of glycerol, two moles of fatty acids, one mole of inositol and one, two, or three moles of phosphoric acids, depending on the number of phosphates on the inositol rings. Phosphoinositides are regarded as the most acidic phospholipids.

The specific fatty acids of PdtIns, and their conformation, employed in the sensory neurons has not been elucidated.

Phosphoinositides

Phosphorylated forms of phosphatidylinositol (PI) are called phosphoinositides and play important roles in lipid signaling, cell signaling and membrane trafficking. The inositol ring can be phosphorylated by a variety of kinases on the three, four and five hydroxyl groups in seven different combinations. However, the two and six hydroxyl group is typically not phosphorylated due to steric hindrance.

All seven variations of the following phosphoinositides have been found in animals:

Phosphatidylinositol monophosphates:

Phosphatidylinositol bisphophosphates:

Phosphatidylinositol trisphophosphate:

These phosphoinositides are also found in plant cells, with the exception of PIP3.[2]

See also

References

  1. ^ a b Mathews, Chrisotphe K.; van Holde, K.E.; Ahern, Kevin G. (2005). Biochemistry Third Edition. 
  2. ^ Muller-Roeber B, Pical C; , (2002). Inositol Phospholipid Metabolism in Arabidopsis. Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C. 

Additional images

External links

  • Phosphatidylinositols at the US National Library of Medicine Medical Subject Headings (MeSH)
  • Phosphatidylinositol at Lipid Library
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