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Prostaglandin E synthase

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Title: Prostaglandin E synthase  
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Subject: Prostaglandin H2
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Prostaglandin E synthase

prostaglandin-E synthase
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human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry Template:PDBe[1]
EC number CAS number IntEnz BRENDA ExPASy KEGG MetaCyc metabolic pathway
PRIAM PDB structures PDBsum
Gene Ontology EGO

Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.[2][3]

The synthase generating PGE2 is a membrane-associated protein.


Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

prostaglandin E synthase (microsomal)
Symbol PTGES
Alt. symbols MGST1L1
Entrez HUGO OMIM RefSeq UniProt Locus q34.3
prostaglandin E synthase 2 (microsomal)
Symbol PTGES2
Alt. symbols C9orf15
Entrez HUGO OMIM RefSeq UniProt Locus q34.12
prostaglandin E synthase 3 (cytosolic)
Symbol PTGES3
Alt. symbols p23, TEBP, cPGES
Entrez HUGO OMIM RefSeq UniProt Locus q13.13


External links

  • Medical Subject Headings (MeSH)
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