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Title: Scn10a  
Author: World Heritage Encyclopedia
Language: English
Subject: Brugada syndrome, Sodium channel, Nav1.7
Publisher: World Heritage Encyclopedia


Sodium channel, voltage-gated, type X, alpha subunit
Available structures
PDB Ortholog search: RCSB
SCN10A Gene

Sodium channel, voltage gated, type X, alpha subunit also known as SCN10A or Nav1.8 is a protein which in humans is encoded by the SCN10A gene.[1]

Nav1.8 is a sodium channel subunit.[2][3][4]


This subtype of voltage-gated sodium channel is expressed in nociceptors and has been proposed as a target for the development of new analgesics.[5]

In 2013, Bezzina & al showed that common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome.[6]


Further reading

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