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Sema4d

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Sema4d

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

PDB rendering based on 1olz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; C9orf164; CD100; M-sema-G; SEMAJ; coll-4
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.[1]

Function

Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.[2]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.[3][4]

During skin damage repairs, SEMA4D interacts with Plexin B2 on gamma delta t cells to play a role in the healing process.[5]

See also

References

  1. ^ Shanks K, Nkyimbeng-Takwi EH, Smith EP, Lipsky MM, DeTolla LJ, Keegan AD, Chapoval SP (2013). "Neuroimmune semaphorin 4D is necessary for optimal lung allergic inflammation". Mol. Immunol. 56 (4): 480–7.  

Further reading

External links


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