Symbol SSPN
Entrez HUGO OMIM Locus p11.2

Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.[1] Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.[2]


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