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Teplizumab

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Teplizumab

Teplizumab?
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target CD3
Identifiers
CAS Registry Number  N
ATC code None
UNII  YesY
Chemical data
Formula C6462H9938N1738O2022S46
Molecular mass 145.8 kDa
 N   

Teplizumab (also known as MGA031 and hOKT3γ1(Ala-Ala)) is a humanized monoclonal antibody that is used as an immunosuppressive drug. The Fc region of this antibody has been engineered to have Fc receptor non-binding (FNB) properties. Teplizumab was originally developed at Columbia University, and was then further developed at MacroGenics, Inc.[1][2]

This antibody has been used in clinical trials with the aim of protecting the remaining β-cells in newly diagnosed type 1 diabetes mellitus patients,[3] but "these agents [i. e. anti-CD3-antibodies] alone do not restore normal glucose control".[4]

Eli Lilly licensed the drug back in 2007 from MacroGenics with a $41 million upfront and a billion dollars pledged for milestones.

It is in Phase-3 clinical trials for Type-1 DM. One-year data from one phase III trial was disappointing.[5]

See also

References

  1. ^
  2. ^
  3. ^
  4. ^
  5. ^

External links

  • MacroGenics, Inc.
  • Tested: A Reboot for the Immune System at Popular Science


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