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Title: Tocofersolan  
Author: World Heritage Encyclopedia
Language: English
Subject: Beta-Tocopherol, Menadiol, 22-Dihydroergocalciferol, Alpha-Tocotrienol, Prosultiamine
Publisher: World Heritage Encyclopedia


CAS number
ChemSpider  YesY
ATC code A11
Jmol-3D images Image 1
Molecular formula (C2H4O)nC33H54O5
Molar mass Variable
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY   YesY/N?)

Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[1] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients suffering from congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[2]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[3]


  1. ^ "Tocophersolan Oral".  
  2. ^ Vedrop Summary of Product Characteristics"".  
  3. ^ Ash, Michael; Ash, Irene. Handbook of Preservatives. p. 568.  

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